Introduction The relationship between thyroid function and major depression has been extensively examined for the past 25 years. The involvement of thyroid hormones in the pathophysiology of Moved Permanently. The document has moved here. Tricyclic and tetracyclic antidepressants (TCAs) have anticholinergic activity, to which elderly patients are particularly sensitive. Tertiary amines such as amitriptyline and trimipramine tend to exhibit greater anticholinergic effects than other agents in the class. Apparently amitriptaline prevents the absorption of thyroid hormones. The hormone replacement needs to be taken at a different time of day and the dose of thyroid hormones may need to be increased when someone is taking amitriptaline. We use cookies to make interactions with our website easy and meaningful, to better understand the use of our services, and to tailor advertising. Nortriptyline, sold under the brand name Pamelor among others, is a medication used to treat depression, neuropathic pain, ADHD, stopping smoking and anxiety. [2] [3] It does not appear to be useful for young people with depression. [3] We investigated: (i) the status of thyroid hormones and their clinical correlates in patients with major depression; (ii) changes in thyroid hormone status after treatment with fluoxetine versus nortriptyline; and (iii) whether blunted thyrotropin-stimulating hormone (TSH) response to thyrotropin. Nortriptyline may cause a condition that affects the heart rhythm (QT prolongation). thyroid supplements, anticholinergic drugs (such as benztropine, belladonna alkaloids), certain drugs for. C 19 H 21 N∙HCl MW = 299.8. Each capsule, for oral administration, contains Nortriptyline hydrochloride equivalent to 10 mg, 25 mg, 50 mg, and 75 mg of Nortriptyline hydrochloride USP. 1. Pharmacopsychiatria. 1981 Mar;14(2):61-5. Nortriptyline and pituitary-thyroid function in affective disorder. Nordgren L, von Schéele C.